Classic Pac-Man video game helps explain nationally recognized arthritis research
Classic Pac-Man video game helps explain nationally recognized arthritis research
Classic Pac-Man video game helps explain nationally recognized arthritis research
By Stephanie Symington
March 12, 2024
Summary
Two University of Calgary scientists, Dr. Antoine Dufour and Dr. Roman Krawetz, have been recognized by Arthritis Society Canada for their groundbreaking research on osteoarthritis. Their study, published in Nature Communications, unveils how the enzyme Tryptase β disrupts joint lubrication, leading to inflammation and joint damage. Using a Pac-Man analogy, they illustrate how Tryptase β acts like the character, consuming a lubricating protein known as PRG4. Despite efforts with protease inhibitors, Tryptase β's impact persists. Their ongoing research aims to develop strategies to mitigate joint damage, including administering drugs to inhibit Tryptase β and injecting laboratory-produced PRG4. This work, supported by Arthritis Society Canada, aims to develop a Tryptase β inhibitor to alleviate osteoarthritis symptoms.
Reference
Symington, S. (2024, March 12). Classic Pac-Man video game helps explain nationally recognized arthritis research. University of Calgary News. Retrieved from https://ucalgary.ca/news/classic-pac-man-video-game-helps-explain-nationally-recognized-arthritis-research